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Common side effects of lipitor

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment. Your doctor may talk to you about the surgery once you are fully awake. He or she may call you at home later to talk to you about the results. Results of any lab tests on tissue samples may not be available for several days. If you miss a dose of Lipitor, take it as soon as possible if you remember within 12 hours of the missed dose. If it is more than 12 hours since the missed dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

How should i take lipitor

The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Each soft gel capsule contains 8 mcg of lubiprostone. Lipitor. I could not take any of the other statins for longer than 2 weeks. I had pain throughout my body. Tried Lipitor in a low dose 10mg. In 6 weeks I started getting same problems with pain. I am tired, don't feel like working out, weak, irritable. My joints hurt and I feel weak in general. Another thing, I think it has lowered my testosterone levels. The hair on my legs is falling out. I don't know that my testosterone levels are down but I feel like it. I just feel terribly weak with low self confidence because I am lethargic in general these days. I need something to get my levels down but statins do not work for me. Anyone have medical suggestions besides exercise and diet. I need a pill, I know that. I am going off Lipitor today. Don't know which way to turn. My doctor thinks I should stay on statins regardless. I don't think I can. I cannot take feeling this way from now on. HELP!

Important information

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. The patient must also be a US resident. Talk with your doctor about what choice is best for you.

What should i avoid while taking lipitor

If general anesthesia is used, you will be asleep and feel nothing. After you wake up, you will feel sleepy for several hours. You may be tired and have some pain for a few days after a laparoscopy. You may have a mild from the tube in your throat to help you breathe. Some people find that certain foods make their symptoms worse. If this happens to you, it makes sense to not eat those foods. But be sure to eat a healthy, varied diet to keep your weight up and to stay strong. There are hundreds of drug interactions that may occur with atorvastatin.



About lipitor

Use Lipitor with caution in the ELDERLY; they may be more sensitive to its effects, especially muscle problems. Sterols and stanols are available in supplements and are also added to foods such as some margarines, orange juice, or yogurt. These can lower LDL, the “bad” cholesterol, by up to 15%. Cholesterol experts recommend 2 grams per day. Talk to your doctor about any concerns you have about the need for the surgery, its risks, how it will be done, or what the results will mean. To help you understand the importance of this test, fill out the What is a document? Partial removal resection of the also can be done. Or it could be that the infection is resistant to the antibiotic your doctor prescribed. Clinical trials report few adverse reactions. Rare cases of contact dermatitis and anaphylaxis have been reported. An increased risk of kidney stones is possible in susceptible individuals. There are options, Golomb says. "Some people may experience improvement when they change to a different drug, while others may lower the dose or stop taking a statin altogether. Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Lipitor. These medications may be counterfeit and potentially unsafe. If you purchase medications online, be sure you are buying from a reputable and valid online pharmacy. Ask your health care provider for advice if you are unsure about the online purchase of any medication. What is atorvastatin Lipitor? In patients with symptoms suggestive of mechanical gastrointestinal obstruction, perform a thorough evaluation to confirm the absence of an obstruction prior to initiating therapy with Amitiza. Patients with certain conditions protein C or S deficiency may be at greater risk. Lubiprostone is a locally acting chloride channel activator that enhances a chloride-rich intestinal fluid secretion without altering sodium and potassium concentrations in the serum. The most frequently reported side effects were nasopharyngitis, arthralgia, diarrhea, pain in extremity, and urinary tract infection. This is an extremely safe drug. Patients taking Amitiza may experience nausea.



Posted 2 days 22 hours ago by Drugs

See package insert for complete prescribing information. Leave your jewelry at home. Any jewelry you wear will need to be taken off before the laparoscopy. IBS symptoms over the past week compared to how you felt before you entered the study? Take this medication by with or without food as directed by your doctor or other professional, usually once a day. It is very important to take it exactly as directed. not increase the dose, take it more frequently, or stop using it unless directed by your doctor. Common side effects like diarrhea, upset stomach, tiredness, memory loss, confusion, and muscle or joint pain. The efficacy of Amitiza in the treatment of opioid-induced constipation in patients receiving opioid therapy for chronic, non-cancer-related pain was assessed in three randomized, double-blinded, placebo-controlled studies. In the mouse carcinogenicity study, there was no significant increase in any tumor incidences. Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. Before taking atorvastatin, tell your doctor if you have a thyroid disorder, muscle pain or weakness, a history of liver or kidney disease, or if you drink more than 2 alcoholic beverages daily. Most reactions resolved within 15 minutes after the injection, but a few people needed emergency medical care. Adhesions, cysts, or abnormal growths, such as tumors, may be seen. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. kemadrin



Takeda Pharmaceuticals America, Inc

In patients taking cyclosporine or the HIV protease inhibitors tipranavir plus ritonavir or the hepatitis C protease inhibitor telaprevir therapy with LIPITOR should be avoided. In patients with HIV taking lopinavir plus ritonavir, caution should be used when prescribing LIPITOR and the lowest dose necessary employed. In patients taking clarithromycin, itraconazole, or in patients with HIV taking a combination of saquinavir plus ritonavir, darunavir plus ritonavir, fosamprenavir, or fosamprenavir plus ritonavir, therapy with LIPITOR should be limited to 20 mg, and appropriate clinical assessment is recommended to ensure that the lowest dose necessary of LIPITOR is employed. Women, especially, should watch for symptoms. They are more likely to get bladder infections than men are. This is the "bad" cholesterol. You should see major changes in your within two to four weeks after starting treatment. Stop taking this medication and tell your doctor right away if you become pregnant. This medication can cause heavy bleeding. To lower the chance of getting cut, bruised, or injured, use great caution with sharp objects like safety razors and nail cutters. Includes only those events associated with treatment possibly, probably, or definitely related, as assessed by the investigator. Damage to an organ or vessel. This may cause more bleeding that needs another surgery to repair. How will ulcerative colitis affect your life? Experts aren't sure what causes it. They think it might be caused by the overreacting to normal bacteria in the digestive tract. Turmeric has a warm, bitter taste and is used extensively as a food flavoring and colorant; it is a primary component of curry powders and some mustards. The spice has a long tradition in Asian medicine to treat problems ranging from flatulence to hemorrhage. Use to treat ringworm, as a poultice, for pain, and in the management of jaundice and hepatitis has been documented. Patients had been receiving stable opioid therapy for at least 30 days prior to screening, which was to continue throughout the 12-week treatment period. At baseline, mean oral morphine equivalent daily doses MEDDs were 99 mg and 130 mg for placebo-treated and Amitiza-treated patients, respectively, in Study 1. Baseline mean MEDDs were 237 mg and 265 mg for placebo-treated and Amitiza-treated patients, respectively, in Study 2. In Study 3, baseline mean MEDDs were 330 mg and 373 mg for placebo-treated and Amitiza-treated patients, respectively. The Brief Pain Inventory-Short Form BPI-SF questionnaire was administered to patients at baseline and monthly during the treatment period to assess pain control. The ratio of to HDL. eked.info lasix



How to take lipitor

Patients must have health insurance and their insurance must cover the qualifying medication for which they seek assistance. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Caduet fluvastatin Lescol lovastatin Altoprev, Mevacor pravastatin Pravachol rosuvastatin Crestor or simvastatin Zocor, Simcor, Vytorin. In rare cases, atorvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. Clinical safety results demonstrated an increased incidence and severity of adverse events in subjects with greater severity of hepatic impairment. Some of the side effects that can occur with atorvastatin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. Lubiprostone drug substance occurs as white, odorless crystals or crystalline powder, is very soluble in ether and ethanol, and is practically insoluble in hexane and water. Amitiza is available as an imprinted, oval, soft gelatin capsule in two strengths. Pink capsules contain 8 mcg of lubiprostone and the following inactive ingredients: medium-chain triglycerides, gelatin, sorbitol, ferric oxide, titanium dioxide, and purified water. Statins boost HDL, the "good" cholesterol, by up to 15%. Nausea: Approximately 8% of patients who received Amitiza 8 mcg twice daily experienced nausea; 1% of patients had severe nausea and 1% of patients discontinued treatment due to nausea. Slideshow What is it used for? Reference Listed Drug RLD is an approved drug product to which new generic versions are compared to show that they are bioequivalent. A drug company seeking approval to market a generic equivalent must refer to the Reference Listed Drug in its Abbreviated New Drug Application ANDA. By designating a single reference listed drug as the standard to which all generic versions must be shown to be bioequivalent, FDA hopes to avoid possible significant variations among generic drugs and their brand name counterpart. Lipitor is to be used only by the patient for whom it is prescribed. Do not share it with other people. endep drugs online



What are the possible side effects of lipitor

Continued How is it treated? Dispense in a tightly closed, light-resistant container. Includes only those events associated with treatment possibly or probably related, as assessed by the investigator. Nausea: Approximately 29% of patients who received Amitiza 24 mcg twice daily experienced nausea; 4% of patients had severe nausea and 9% of patients discontinued treatment due to nausea. The rate of nausea associated with Amitiza 24 mcg twice daily was lower among male 8% and elderly 19% patients. No patients in the clinical studies were hospitalized due to nausea. Study 2, respectively. Similarly, the time to first SBM was shorter for patients receiving Amitiza than for those receiving placebo. Use Lipitor as directed by your doctor. Check the label on the medicine for exact dosing instructions. The lawsuits prominently claim that Lipitor caused in the plaintiffs. Some of your pubic may be shaved. The starting dose of atorvastatin for high lipid levels or for prevention of heart events may range between 10 milligrams mg to 80 mg by mouth once a day. Atorvastatin may be taken at any time of the day without regard for meals. Your doctor may adjust doses every 2 to 4 weeks. Less common adverse reactions: The following adverse reactions assessed by investigator as probably or definitely related to treatment occurred in less than 1% of patients receiving Amitiza 24 mcg twice daily in clinical studies, occurred in at least two patients, and occurred more frequently in patients receiving study drug than those receiving placebo: fecal incontinence, muscle cramp, defecation urgency, frequent bowel movements, hyperhidrosis, pharyngolaryngeal pain, intestinal functional disorder, anxiety, cold sweat, constipation, cough, dysgeusia, eructation, influenza, joint swelling, myalgia, pain, syncope, tremor, decreased appetite. Older adults may be at greater risk for bleeding while using this drug.



Lipitor warnings

When these two medicines are taken together, your body may not process your cholesterol medicine properly. Ulcerative colitis affects everyone differently. Your doctor will help you find treatments that reduce your symptoms and help you avoid new flare-ups. To get your cholesterol down to lower your risk of cardiovascular disease your doctor may recommend, though, that you still need a statin. These powerful cholesterol-lowering medicines include and among others. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Eating grapefruit or drinking grapefruit juice may increase the amount of Lipitor in your blood, which may increase your risk for serious side effects. The risk may be greater with large amounts of grapefruit or grapefruit juice. Avoid large amounts of grapefruit or grapefruit juice eg, more than 1 quart daily. Talk with your doctor or pharmacist if you have questions about including grapefruit or grapefruit juice in your diet while you are taking Lipitor. The hospital or surgery center may send you instructions on how to get ready for your laparoscopy or a nurse may call you with instructions before your surgery. The clinical relevance of the effect of food on the pharmacokinetics of lubiprostone is not clear. However, lubiprostone was administered with food and water in a majority of clinical trials. generic version of combivent



Lipitor ingredients

Tissue samples can be taken for through the tube laparoscope. There may be bruising around the incisions for a few days. You may have some pain around the incisions. An may be present. Physicians and patients should periodically assess the need for continued therapy. Atorvastatin reduces levels of "bad" cholesterol low-density lipoprotein, or LDL and triglycerides in the blood, while increasing levels of "good" cholesterol high-density lipoprotein, or HDL. cost dostinex uk



Pfizer is a WebMD sponsor

Where can I get more information? This drug rarely has caused very serious possibly fatal problems if its effects lead to small usually at the beginning of treatment. Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage. Other tools can be used to take tissue samples, fix damage, or drain cysts. A laser may be attached to the laparoscope to help with the surgery. Avoid use of Amitiza in patients with severe diarrhea. Patients should be aware of the possible occurrence of diarrhea during treatment. What should I avoid while taking atorvastatin Lipitor? The blood levels of your cholesterol medicine may increase and cause toxic effects. Inform patients that they may experience diarrhea during treatment with Amitiza. Avoid eating foods that are high in fat or cholesterol. Atorvastatin will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan. Hoarseness in your voice that lasts more than a few days or gets worse. B6C3F1 mice and one in Sprague-Dawley rats were conducted with lubiprostone. These drugs may increase the risk of bleeding problems if taken during treatment with warfarin. Table 2 presents data for the adverse reactions that occurred in at least 1% of patients who received Amitiza 24 mcg twice daily and that occurred more frequently with study drug than placebo. Two double-blinded, placebo-controlled studies of similar design were conducted in patients with IBS-C. IBS was defined as abdominal pain or discomfort occurring over at least 6 months with two or more of the following: 1 relieved with defecation; 2 onset associated with a change in stool frequency; and 3 onset associated with a change in stool form. St. John's wort, among others. Examination of gender and race subgroups did not identify differences in response to Amitiza among these subgroups. avelox



Is this topic for you?

If any of these effects persist or worsen, tell your doctor or promptly. Of course not. Doctors say the best way to protect your heart is to make healthy lifestyle changes while taking a statin. Lipitor atorvastatin US prescribing information. Pfizer Inc. March, 2015. If your symptoms are mild, you may only need to use over-the-counter medicines for diarrhea such as . Talk to your doctor before you take these medicines. Atorvastatin may also be used for purposes not listed in this medication guide. After a single oral dose of 72 mcg of 3H-labeled lubiprostone, 60% of total administered radioactivity was recovered in the urine within 24 hours and 30% of total administered radioactivity was recovered in the feces by 168 hours. Lubiprostone and M3 are only detected in trace amounts in human feces. Lowering high cholesterol and triglycerides in certain patients. It also increases high-density lipoprotein HDL, "good" cholesterol levels. It is used along with an appropriate diet. It is used in certain patients to reduce the risk of heart attack, stroke, chest pain caused by angina, or blood vessel blockage. It is also used in certain patients to reduce the risk of hospitalization for congestive heart failure, or the need for medical procedures to open blocked heart blood vessels. It may also be used for other conditions as determined by your doctor.



Prescribing information for lipitor

Diarrhea: Approximately 8% of patients who received Amitiza 24 mcg twice daily experienced diarrhea; 2% of patients had severe diarrhea and 1% of patients discontinued treatment due to diarrhea. And Lipitor, Milani says, doesn't cause side effects any more often than other statins. Lipitor Nerve Damage? IBS-C were nausea, diarrhea, and abdominal pain. The primary efficacy analysis was a comparison of the proportion of "overall responders" in each arm. A patient was considered an "overall responder" if the criteria for being designated a "monthly responder" were met in at least 2 of the 3 months on study. A "monthly responder" was defined as a patient who had reported "significantly relieved" for at least 2 weeks of the month or at least "moderately relieved" in all 4 weeks of that month. During each monthly evaluation period, patients reporting "moderately worse" or "significantly worse" relief, an increase in rescue medication use, or those who discontinued due to lack of efficacy, were deemed non-responders. Atorvastatin is used in adults and children who are at least 10 years old. Bleeding or drainage from the stitches. Can Generic Manufacturers Be Trusted? FDA pregnancy category X. This medication can harm an unborn baby or cause birth defects. Do not take atorvastatin if you are pregnant. Stop taking this medication and tell your doctor right away if you become pregnant. Use effective birth control to avoid pregnancy while you are taking atorvastatin. People who were taking statin drugs were more likely to experience decreased energy, upon exertion, or both, when compared with those who were not taking statins. The effects were more pronounced among women. How can I get my LDL or bad cholesterol under control? An organ may be abnormal in size, shape, or position. It is only a small chance, but all they have to do is discontinue the drug and give us a call. I tell them the truth; I would not expect this to happen. These are infrequent side effects. What other drugs will affect atorvastatin Lipitor? suprax pills order online payment



SBMs associated with straining

Additionally, in vitro studies in human liver microsomes demonstrate that lubiprostone does not inhibit cytochrome P450 isoforms 3A4, 2D6, 1A2, 2A6, 2B6, 2C9, 2C19, or 2E1, and in vitro studies of primary cultures of human hepatocytes show no induction of cytochrome P450 isoforms 1A2, 2B6, 2C9, and 3A4 by lubiprostone. Take Amitiza orally with food and water. Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Do not break an atorvastatin tablet unless your doctor has told you. No signs of disease such as such as appendicitis or infection are seen. This medication can cause serious bleeding if it affects your clotting proteins too much shown by unusually high INR lab results. Even if your doctor stops your medication, this risk of bleeding can continue for up to a week. Arrange for someone to drive you home after the laparoscopy. The primary efficacy analysis was a comparison of the proportion of "overall responders" in each treatment arm. The longer you have had ulcerative colitis, the greater your risk. Talk to your doctor about your need for screening. These tests help find early, when it is easier to treat. In severe cases, people may have diarrhea 10 to 20 times a day. In addition, heart healthy, not necessarily low-calorie, diets are recommended. As always, exercise is important to help reduce the risk for heart disease by keeping blood pressure and cholesterol levels under check. Finally, a and waist measurement can help uncover obesity risk factors, too. At the very least, patients 40 to 75 years of age should know their 10-year risk of heart attack and stroke and discuss this number with their doctor. Discussions with a healthcare provider can help define individual needs for statin treatment. Many affordable generic statins are available, and patients should discuss medication cost with their doctors so they can afford and continue this treatment. There is a small chance for problems from a laparoscopy. If you have severe symptoms and medicines don't help, you may need surgery to remove your colon. Removing the colon cures ulcerative colitis. During clinical development of Amitiza for CIC, OIC, and IBS-C, 1234 patients were treated with Amitiza for 6 months and 524 patients were treated for 1 year not mutually exclusive. Muscle damage can be lasting, but patients usually experience muscle aches as an early warning sign, Milani says. combigan



Lipitor adult dosage

Is this topic for you? Keep container tightly closed. An extra patient leaflet is available with Lipitor. Talk to your pharmacist if you have questions about this information. Amitiza is available as an oval, gelatin capsule containing 8 mcg or 24 mcg of lubiprostone. Follow the diet and exercise program given to you by your health care provider. Less common adverse reactions: The following adverse reactions assessed by investigator as probably related to treatment occurred in less than 1% of patients receiving Amitiza 8 mcg twice daily in clinical studies, occurred in at least two patients, and occurred more frequently in patients receiving study drug than those receiving placebo: dyspepsia, loose stools, vomiting, fatigue, dry mouth, edema, increased alanine aminotransferase, increased aspartate aminotransferase, constipation, eructation, gastroesophageal reflux disease, dyspnea, erythema, gastritis, increased weight, palpitations, urinary tract infection, anorexia, anxiety, depression, fecal incontinence, fibromyalgia, hard feces, lethargy, rectal hemorrhage, pollakiuria. Teva Pharmaceutical Industries, says the three-times-per-week regimen “will be available to patients within days. Continue to take Lipitor even if you feel well. Do not miss any doses. Amitiza is indicated for the treatment of opioid-induced constipation OIC in adults with chronic non-cancer pain. Mark Jay Krum, a lawyer based in New York and Philadelphia, last Wednesday filed the suits in New York State Supreme Court on behalf of patients in New York and Atlanta. Amitiza is contraindicated in patients with known or suspected mechanical gastrointestinal obstruction. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. Jacobson TA. Comparative pharmacokinetic interaction profiles of pravastatin, simvastatin, and atorvastatin when coadministered with cytochrome P450 inhibitors. AB1, AB2, AB3, etc. Crohn's can affect any part of the digestive tract.



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Lipitor dosage


What is atorvastatin Lipitor?

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. Your pharmacist can provide more information about atorvastatin. This program provides uninsured patients with savings on their prescriptions at the pharmacy. What is the most important information I should know about atorvastatin Lipitor? Diarrhea; joint pain; mild sore throat; nausea; runny or stuffy nose; stomach upset.

How to use lipitor

In many cases laparoscopy can be done instead of laparotomy surgery that uses a larger incision in the belly. Laparoscopy can be less stressful and may have less problems and lower costs than laparotomy for minor surgeries. It can often be done without needing to stay overnight in the hospital. Higher doses are associated with adverse GI effects. Inform patients that they may experience syncope and hypotension after taking the first dose or subsequent doses of Amitiza. Syncope and hypotension generally resolve prior to the next dose, but may recur with repeat dosing. The organs are normal in size, shape, and position.

Indications and usage of lipitor

This medication may cause bleeding. Daily use of alcohol while using this medicine will increase your risk for stomach bleeding and may also affect how this medication works. Limit beverages. Ask your doctor or pharmacist about how much alcohol you may safely drink. Check with your pharmacist about how to dispose of unused medicine. The suit filed by Michael Mazzariello, a 47-year-old New Yorker, says his use of -- the family of -lowering drugs to which Lipitor belongs -- left him with debilitating muscle damage and extensive memory loss.

Lipitor drug interactions

Milani tells WebMD. "There are only two safety issues. One is -related issues, and the other is muscle damage. Avoid getting injections into the muscles. If you must have an injection into a muscle for example, a it should be given in the arm. They can also help you find a pharmacy that carries Copaxone. It usually affects the lower section sigmoid colon and the rectum. But it can affect the entire colon. Make sure your concerns are valid before you reject a statin -- their benefits to your are noteworthy. Can Exercise and Diet Lower Your Cholesterol Enough?

Lipids are found in your and are stored in tissues. They are an important part of cells, and they help keep your body working normally. How is Atorvastatin Dosage Determined? During a 4-week randomized withdrawal period following Study 1, patients who received Amitiza during the 12-week treatment period were re-randomized to receive either placebo or to continue treatment with Amitiza. In Amitiza-treated patients who were "overall responders" during Study 1 and who were re-randomized to placebo, SBM frequency rates did not result in worsening compared to baseline. Lipitor may cause liver problems. Rarely, severe and sometimes fatal liver problems have been reported in patients taking "statin" medicines, including Lipitor. Your risk of developing liver problems may be greater if you drink alcohol daily or in large amounts, or if you have a history of liver problems. Check with your doctor before drinking alcohol while you are taking Lipitor. Tell your doctor right away if you experience symptoms of liver problems eg, dark urine; pale stools; severe or persistent nausea, loss of appetite, or stomach pain; unusual tiredness; yellowing of the skin or eyes.

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